Sick cats do not survive to reproductive age: under culture conditions 8-month-old male or female,

What are the common people of the American race horses, quarter horse and norwegian forest cats? This question is only superficially seems to make no sense. The answer is not there, and is unfortunately quite grim: As for GSD type IV, fortunately quite rare hereditary disease associated with glucose metabolism pathway. GSD type IV, or wring all the heads of the hydra
Abbreviation GSD comes from the English name Glycogen Storage desease, which is translated into Polish as glycogen storage disease. The presence of the Norwegian forest cat has been described relatively recently, philips senseo in 1988 by Professor John C. Fyfe'a the USA. The occurrence of GSD is not limited to the United States, genetic philips senseo studies conducted in specialized laboratories confirmed philips senseo cases of GSD also in Europe. philips senseo More recently, philips senseo we know that carriers are also present in Poland, which is a direct impetus to the creation of this article.
As the name implies, glycogen storage disease is associated with pathological storage of glycogen in muscle cells, hepatocytes, and neurons, causing philips senseo them damage and, consequently, impaired functioning of the various organs in varying philips senseo degrees, to failure. Improper accumulation of glycogen in cells is induced glycogen branching enzyme deficiency, GBE, one of the glucose metabolic pathway enzymes required to produce a branched molecular structure of glycogen, allowing the release of glucose (necessary for obtaining energy) of glycogen. The disease is always fatal, are not currently known drugs that can stop its development.
Norwegian Forest Cats observed two different types of development GSD. The first, more common, causes the death of kittens just before or just after birth because of severe hypoglycemia and induced her cardiac arrest. In rare cases, the administration of glucose kocięciu can survive, but only delayed judgment.
Kitten develops apparently normally for about five months, when they begin to experience the first signs of progressive philips senseo disease: muscle-nerve degeneration manifested by tremor of the head, lack of coordination, muscle atrophy, enlarged liver and spleen, liver cirrhosis and ascites. Death of the animal occurs around the age of eight to nine months due to irreversible organ failure.
Sick cats do not survive to reproductive age: under culture conditions 8-month-old male or female, in addition showing signs of the disease are not included in breeding plans. This means that the sick cats have no chance of further transmission of the defective gene, this is done almost exclusively through carriers.
As I mentioned earlier, the disease is incurable and always fatal. This does not mean, however, that breeders and enthusiasts philips senseo of Norwegian philips senseo forest cats need to panic, that here we have the plague, which at any moment decimate the ranks of these beautiful cats. Or worse, that the race is cherlawa and sickly by nature, which had hitherto been carefully concealed. None of these things, panic, moreover, is never a good adviser.
First of all, it should be noted that the disease is truly rare, and the identification of the Norwegian forest cat can most probably attributed to the fact that it was already known and described in humans (more exposed to a GSD, not only the type IV). In addition, GSD type IV is an inherited disease, not contagious, inherited as an autosomal recessive trait. That is to say that the symptoms of the disease need to make two copies of the mutated gene causing enzyme deficiency GBE, one from each parent. Carriers having one copy of the gene to be clinically philips senseo healthy and not in any way disease risk. Recessive mutations difficult to identify the nature of the vector, since no laboratory testing with the exception of a genetic test is not able to demonstrate the presence of a mutant gene in their DNA. Fortunately, such a genetic test exists and is offered by a number philips senseo of laboratories performing tests commercially philips senseo available.
The occurrence of GSD type IV in Norwegian Forest Cat has been found relatively recently, the genetic test for mutations causing the disease is available from just a few years. It is very rare and its symptoms (if it occurs, in kittens who are children of two vectors) are sometimes confused with those of serologic incompatibility between the mother and kittens philips senseo (infantile-onset form) or underdevelopment of the cerebellum after meningitis and brain, as a result of FIP and toxoplasmosis (figure juvenile). A clear decision can only genetic test again.
Perhaps all factors must be attributed to the fact that most veterinarians are not aware of the existence of such a disease and, consequently, does not inform the Norwegian forest cat breeders to carry out tests of breeding cats for GSD type IV